8. San Diego
Median listing price: $659,000
Percentage of households that can’t afford a home: 65.9 percent
Only about one-third of San Diego residents can afford a home with a median list price of $659,000. That’s because the city’s median household income of $71,481 falls significantly short of the $111,160 needed to pay a monthly mortgage of $2,779 on a median-priced home.